TSPYL2
Function
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Post-translational modifications
Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
Sequence Similarities
Belongs to the nucleosome assembly protein (NAP) family.
Tissue Specificity
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Cellular localization
- Nucleus
- Cytoplasm
- Enriched in transcriptionally active regions of chromatin in neurons.
Alternative names
CDA1, DENTT, TSPX, HRIHFB2216, TSPYL2, Testis-specific Y-encoded-like protein 2, TSPY-like protein 2, Cell division autoantigen 1, Cutaneous T-cell lymphoma-associated antigen se20-4, Differentially-expressed nucleolar TGF-beta1 target protein, Nuclear protein of 79 kDa, CTCL-associated antigen se20-4, NP79