TSSK1B
Function
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
Post-translational modifications
Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Tissue Specificity
Testis-specific. Present in sperm (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Cell projection
- Cilium
- Flagellum
- In spermatozoa, present in the sperm head and in the flagellum.
Alternative names
SPOGA1, SPOGA4, STK22A, STK22D, TSSK1, FKSG81, TSSK1B, Testis-specific serine/threonine-protein kinase 1, TSK-1, TSK1, TSSK-1, Testis-specific kinase 1, Serine/threonine-protein kinase 22A