TSSK6
Function
Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity).
Post-translational modifications
Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Tissue Specificity
Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Flagellum axoneme
- Nucleus
- Component of the sperm flagellar doublet microtubules. Also localizes in the nucleus of elongating spermatids.
Alternative names
SSTK, FKSG82, TSSK6, Testis-specific serine/threonine-protein kinase 6, TSK-6, TSSK-6, Testis-specific kinase 6, Cancer/testis antigen 72, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase, CT72