TTBK1
Function
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Sequence Similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Tissue Specificity
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
Cellular localization
- Cytoplasm
Alternative names
BDTK, KIAA1855, TTBK1, Tau-tubulin kinase 1, Brain-derived tau kinase