Ttbk2
Function
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Required for recruitment of CPLANE2 and INTU to the mother centriole (PubMed:29038301).
Sequence Similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Cellular localization
- Cell projection
- Cilium
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- Cytoplasm
- Cytosol
- Nucleus
- Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). May also be present in cytosol and, at lower level in the nucleus (By similarity).
Alternative names
Bby, Kiaa0847, Ttbk1, Ttbk2, Tau-tubulin kinase 2, Protein bartleby