TTC21A
Developmental stage
Expressed in preleptotene spermatocytes, pachytene spermatocytes, round spermatids and elongated spermatids (at protein level).
Function
Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735).
Involvement in disease
Spermatogenic failure 37
SPGF37
An autosomal recessive infertility disorder characterized by asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic abnormalities, primarily consisting of short or absent flagella, and neck defects at the head-tail junction.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the TTC21 family.
Tissue Specificity
Strongly expressed in testis.
Alternative names
STI2, TTC21A, Tetratricopeptide repeat protein 21A, TPR repeat protein 21A, Stress-inducible protein 2