TTC28
Function
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
Tissue Specificity
Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Spindle
- Cytoplasm
- Cytoskeleton
- Spindle pole
- Midbody
- At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity).
Alternative names
KIAA1043, TPRBK, TTC28, Tetratricopeptide repeat protein 28, TPR repeat protein 28, TPR repeat-containing big gene cloned at Keio