TTF2
Function
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
Sequence Similarities
Belongs to the SNF2/RAD54 helicase family.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
Alternative names
Transcription termination factor 2, Lodestar homolog, RNA polymerase II termination factor, Transcription release factor 2, F2, HuF2, TTF2