TUBG2

Function

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Post-translational modifications

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Sequence Similarities

Belongs to the tubulin family.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome

Alternative names

Tubulin gamma-2 chain, Gamma-2-tubulin, TUBG2

Database links

swissprot:Q9NRH3 entrezGene:27175 entrezGene:7283 swissprot:P23258 omim:605785 omim:191135