Tumor necrosis factor alpha-induced protein 8

Developmental stage

Expressed at high levels in the fetal liver, lung and kidney.

Function

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Sequence Similarities

Belongs to the TNFAIP8 family.

Tissue Specificity

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Cellular localization

• Cytoplasm

Alternative names

Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, SCC-S2, TNF-induced protein GG2-1, NDED, TNFAIP8

Database links

swissprot:O95379 genbank:NP_055165.1 omim:612111 entrezGene:25816