TXNDC11
Function
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Sequence Similarities
Belongs to the protein disulfide isomerase family.
Tissue Specificity
Widely expressed at low level. Expressed at higher level in thyroid and prostate.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
EFP1, TXNDC11, Thioredoxin domain-containing protein 11, EF-hand-binding protein 1