Tyrosine-protein phosphatase non-receptor type 7
Function
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Post-translational modifications
Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H(2)O(2)) or with antigen enhanced oxidation of active site cysteine (By similarity).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Tissue Specificity
Expressed exclusively in thymus and spleen.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
Alternative names
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, Protein-tyrosine phosphatase LC-PTP, HEPTP, PTPN7