TYSND1
Function
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
Post-translational modifications
Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.
Sequence Similarities
Belongs to the peptidase S1B family.
Cellular localization
- Peroxisome
Alternative names
Peroxisomal leader peptide-processing protease, Trypsin domain-containing protein 1, TYSND1