TYW5
Function
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
Pathway
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
Sequence Similarities
Belongs to the TYW5 family.
Alternative names
C2orf60, TYW5, tRNA wybutosine-synthesizing protein 5, hTYW5, tRNA yW-synthesizing protein 5, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase