Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Protein modification; protein ubiquitination.
Belongs to the ubiquitin-activating E1 family.
Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
MOP4, UBE1L2, UBA6, Ubiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, Ubiquitin-activating enzyme E1-like protein 2, MOP-4, E1-L2
Proteins
Immuno-oncology
117970Da
We found 4 products in 2 categories
ab228918
ab177514
ab163029