UBE2B

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Cellular localization

• Cell membrane
• Nucleus
• In peripheral neurons, expressed both at the plasma membrane and in nuclei.

Alternative names

• Ubiquitin-conjugating enzyme E2 B
• E2 ubiquitin-conjugating enzyme B
• RAD6 homolog B
• Ubiquitin carrier protein B
• Ubiquitin-conjugating enzyme E2-17 kDa
• Ubiquitin-protein ligase B
• HR6B
• hHR6B
• UBCH1
• RAD6B
• UBE2B

Database links

• entrezGene:7320
• omim:179095
• swissprot:P63146

Target type

Proteins

Molecular weight

17312Da