UBE2E1
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
ISGylation suppresses ubiquitin E2 enzyme activity.
Autoubiquitinated in vitro.
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Cellular localization
- Nucleus
Alternative names
UBCH6, UBE2E1, Ubiquitin-conjugating enzyme E2 E1, (E3-independent) E2 ubiquitin-conjugating enzyme E1, E2 ubiquitin-conjugating enzyme E1, UbcH6, Ubiquitin carrier protein E1, Ubiquitin-protein ligase E1