UBE2E2
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Autoubiquitinated in vitro.
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Alternative names
UBCH8, UBE2E2, Ubiquitin-conjugating enzyme E2 E2, E2 ubiquitin-conjugating enzyme E2, UbcH8, Ubiquitin carrier protein E2, Ubiquitin-protein ligase E2