UBE2E3
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Tissue Specificity
Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
Cellular localization
- Nucleus
- Cytoplasm
- Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
Alternative names
UBCE4, UBCH9, UBE2E3, Ubiquitin-conjugating enzyme E2 E3, E2 ubiquitin-conjugating enzyme E3, UbcH9, Ubiquitin carrier protein E3, Ubiquitin-conjugating enzyme E2-23 kDa, Ubiquitin-protein ligase E3