UBE2J2
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Auto-ubiquitinated.
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
Alternative names
NCUBE2, UBE2J2, Ubiquitin-conjugating enzyme E2 J2, E2 ubiquitin-conjugating enzyme J2, Non-canonical ubiquitin-conjugating enzyme 2, NCUBE-2