UBE2L6
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
ISGylated.
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Tissue Specificity
Present in natural killer cells (at protein level).
Alternative names
UBCH8, UBE2L6, Ubiquitin/ISG15-conjugating enzyme E2 L6, E2 ubiquitin-conjugating enzyme L6, Retinoic acid-induced gene B protein, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, RIG-B