UBE2V2

Function

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Tissue specificity

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.

Alternative names

• Ubiquitin-conjugating enzyme E2 variant 2
• DDVit 1
• Enterocyte differentiation-associated factor 1
• Enterocyte differentiation-promoting factor 1
• MMS2 homolog
• Vitamin D3-inducible protein
• EDAF-1
• EDPF-1
• UEV2
• MMS2
• UBE2V2

Database links

• entrezGene:7336
• omim:603001
• swissprot:Q15819

Target type

Proteins

Molecular weight

16363Da