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UBE3C
Domain
The C-terminal is necessary and sufficient for the poly-ubiquitin chain assembly.
Function
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Pathway
Protein modification; protein ubiquitination.
Tissue specificity
Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
Cellular localization
- Nucleus
Alternative names
- Ubiquitin-protein ligase E3C
- HECT-type ubiquitin transferase E3C
- HectH2
- KIAA10
- KIAA0010
- UBE3C
Database links
Target type
Proteins
Molecular weight
123923Da