UBE3D
Domain
The C-terminal half (AA 188-389) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi-ubiquitination) in a HECT-like sequence dependent manner.
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme).
Cellular localization
- Cytoplasm
Alternative names
C6orf157, H10BH, UBE2CBP, UBE3D, E3 ubiquitin-protein ligase E3D, HECT-type E3 ubiquitin transferase E3D, UbcH10-binding protein with a HECT-like domain, Ubiquitin-conjugating enzyme E2C-binding protein