Erasin

The UBX domain is required for interaction with VCP.

The intramembrane domain also contains the signal for ER targeting.

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).

Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).

• Endoplasmic reticulum membrane
• Peripheral membrane protein
• Nucleus envelope
• Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.

KIAA0242, UBXD2, UBXDC1, UBXN4, UBX domain-containing protein 4, Erasin, UBX domain-containing protein 2

• entrezGene:23190
• omim:611216
• swissprot:Q92575

Proteins

56778Da