UBXN4
Domain
The UBX domain is required for interaction with VCP.
The intramembrane domain also contains the signal for ER targeting.
Function
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
Tissue Specificity
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
Cellular localization
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Nucleus envelope
- Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Alternative names
KIAA0242, UBXD2, UBXDC1, UBXN4, UBX domain-containing protein 4, Erasin, UBX domain-containing protein 2