UBXN6
Domain
The UBX domain lacks key residues critical for VCP binding.
Function
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).
Tissue Specificity
Enhanced expression in testis.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
- Nucleus
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Early endosome membrane
- Peripheral membrane protein
- Late endosome membrane
- Peripheral membrane protein
- Lysosome membrane
- Peripheral membrane protein
- Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622).
Alternative names
UBXD1, UBXDC2, UBXN6, UBX domain-containing protein 6, UBX domain-containing protein 1