UCHL5

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Sequence Similarities

Belongs to the peptidase C12 family.

Cellular localization

• Cytoplasm
• Nucleus
• Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.

Alternative names

UCH37, AD-019, CGI-70, UCHL5, Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5

Database links

swissprot:Q9Y5K5 entrezGene:51377 omim:610667 swissprot:Q16186