UCKL1

Function

May contribute to UTP accumulation needed for blast transformation and proliferation.

Pathway

Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Post-translational modifications

Ubiquitinated by RNF19B; which induces proteasomal degradation.

Sequence similarities

Belongs to the uridine kinase family.

Tissue specificity

Ubiquitous.

Cellular localization

• Cytoplasm
• Nucleus
• EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Alternative names

• Uridine-cytidine kinase-like 1
• URKL1
• UCKL1
• F538

Database links

• entrezGene:54963
• omim:610866
• swissprot:Q9NWZ5

Target type

Proteins

Molecular weight

61141Da