UDP-glucuronosyltransferase 1A4
Function
Isoform 1
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).
Isoform 2
Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
Sequence Similarities
Belongs to the UDP-glycosyltransferase family.
Tissue Specificity
Isoform 1
Expressed in liver (PubMed:1339448, PubMed:18004212). Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in esophagus (PubMed:18004212). Not expressed in skin (PubMed:1339448).
Isoform 2
Expressed in liver, kidney, colon, esophagus and small intestine.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
GNT1, UGT1, UGT1A4, UDP-glucuronosyltransferase 1A4, Bilirubin-specific UDPGT isozyme 2, UDP-glucuronosyltransferase 1-4, UDP-glucuronosyltransferase 1-D, hUG-BR2, UDPGT 1-4, UGT1*4, UGT1-04, UGT1.4, UGT-1D, UGT1D