UGGT2
Function
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Pathway
Protein modification; protein glycosylation.
Sequence Similarities
Belongs to the glycosyltransferase 8 family.
Tissue Specificity
Higher levels in kidney, pancreas, heart, and skeletal muscle.
Cellular localization
- Endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment
Alternative names
UGCGL2, UGT2, UGGT2, UDP-glucose:glycoprotein glucosyltransferase 2, hUGT2, UDP--Glc:glycoprotein glucosyltransferase 2, UDP-glucose ceramide glucosyltransferase-like 1