Ugt2b
Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone.
Post-translational modifications
Autoacylation in vitro.
Sequence Similarities
Belongs to the UDP-glycosyltransferase family.
Cellular localization
- Microsome membrane
- Single-pass membrane protein
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
Ugt2b2, Ugt2b, UDP-glucuronosyltransferase 2B2, UDPGT 2B2, 3-hydroxyandrogen-specific UDPGT, RLUG23, UDPGTr-4