UHMK1
Developmental stage
Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).
Function
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Tissue Specificity
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
Cellular localization
- Nucleus
Alternative names
KIS, KIST, UHMK1, Serine/threonine-protein kinase Kist, Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, U2AF homology motif kinase 1, P-CIP2