UL130
Function
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection.
Sequence Similarities
Belongs to the HHV-5 UL130 protein family.
Cellular localization
- Virion membrane
- Found as a pentameric complex at the surface of virion envelope.
Alternative names
Uncharacterized protein UL130, UL130