UL42
Function
Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.
Sequence Similarities
Belongs to the herpesviridae DNA polymerase processivity factor family.
Cellular localization
- Host nucleus
Alternative names
DNA polymerase processivity factor, DNA-binding protein UL42, Polymerase accessory protein, PAP, UL42