UL48
Domain
The transcriptional activation region seems to target many proteins of the RNA polymerase II transcription machinery.
Function
Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity).
May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.
Sequence Similarities
Belongs to the herpesviridae tegument protein VP16 protein family.
Cellular localization
- Virion tegument
- Host nucleus
Alternative names
Tegument protein VP16, Alpha trans-inducing protein, Alpha-TIF, ICP25, Vmw65, UL48