UL99
Function
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
Post-translational modifications
Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.
Sequence Similarities
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.
Cellular localization
- Virion tegument
- Virion membrane
- Lipid-anchor
- Host cell membrane
- Lipid-anchor
- Cytoplasmic side
- Host Golgi apparatus membrane
- Lipid-anchor
- Cytoplasmic side
- Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Alternative names
Cytoplasmic envelopment protein 3, UL99