ULBP1

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Belongs to the MHC class I family.

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Endoplasmic reticulum
• In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.

N2DL1, RAET1I, ULBP1, UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1

• entrezGene:80329
• omim:605697
• swissprot:Q9BZM6

Proteins

Immuno-oncology

27997Da