ULBP1
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sequence Similarities
Belongs to the MHC class I family.
Tissue Specificity
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Endoplasmic reticulum
- In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
Alternative names
N2DL1, RAET1I, ULBP1, UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1