ULBP1

Function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Sequence similarities

Belongs to the MHC class I family.

Tissue specificity

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Endoplasmic reticulum
• In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.

Alternative names

• UL16-binding protein 1
• ALCAN-beta
• NKG2D ligand 1
• Retinoic acid early transcript 1I
• N2DL-1
• NKG2DL1
• RAET1I
• N2DL1
• ULBP1

Database links

• entrezGene:80329
• omim:605697
• swissprot:Q9BZM6

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

27997Da