ULBP2
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sequence Similarities
Belongs to the MHC class I family.
Tissue Specificity
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Endoplasmic reticulum
- Secreted
- In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
Alternative names
N2DL2, RAET1H, UNQ463/PRO791, ULBP2, UL16-binding protein 2, ALCAN-alpha, NKG2D ligand 2, Retinoic acid early transcript 1H, N2DL-2, NKG2DL2