UNC119B
Domain
Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
Function
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.
Sequence Similarities
Belongs to the PDE6D/unc-119 family.
Cellular localization
- Cell projection
- Cilium
- Enriched at the transition zone and extended into the proximal end of the cilium.
Alternative names
Protein unc-119 homolog B, UNC119B