UNC5A
Domain
The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
Function
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Post-translational modifications
Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
The two extracellular TSRs of UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface.
Sequence Similarities
Belongs to the unc-5 family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Membrane raft
- Cell projection
- Neuron projection
- The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones.
Alternative names
KIAA1976, UNC5H1, UNC5A, Netrin receptor UNC5A, Protein unc-5 homolog 1, Protein unc-5 homolog A