UNK
Function
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).
Sequence Similarities
Belongs to the unkempt family.
Cellular localization
- Cytoplasm
Alternative names
KIAA1753, ZC3H5, ZC3HDC5, UNK, RING finger protein unkempt homolog, Zinc finger CCCH domain-containing protein 5