Uroplakin III

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Belongs to the uroplakin-3 family.

Expressed in ureter.

• Endoplasmic reticulum membrane
• Single-pass type I membrane protein
• Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

UPK3, UPK3A, Uroplakin-3a, UP3a, Uroplakin III, UPIII

• swissprot:O75631

Proteins

Oncology

30670Da