UPK3A
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
Involvement in disease
Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
Sequence Similarities
Belongs to the uroplakin-3 family.
Tissue Specificity
Expressed in ureter.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Alternative names
UPK3, UPK3A, Uroplakin-3a, UP3a, Uroplakin III, UPIII