ureB
Function
Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
Pathway
Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.
Post-translational modifications
Carboxylation allows a single lysine to coordinate two nickel ions.
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
Cellular localization
- Cytoplasm
- Also associates with the outer membrane upon autolysis of neighboring bacteria.
Alternative names
hpuB, HP_0072, ureB, Urease subunit beta, Urea amidohydrolase subunit beta