Uricase
Function
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Pathway
Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.
Post-translational modifications
Acetylation of Lys-118, Lys-164 and Lys-290 is observed in liver mitochondria from fasted mice but not from fed mice. May be deacetylated by Sirt5; however it is unclear whether Sirt5 mediates deacetylation or desuccinylation of Uox; additional evidence is required to validate these results (PubMed:23085393).
Sequence Similarities
Belongs to the uricase family.
Cellular localization
- Peroxisome
- Mitochondrion
Alternative names
Uricase, Urate oxidase, Uox