Uridine phosphorylase 2
Function
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12849978, PubMed:21855639). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed:12849978).
Pathway
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
Sequence Similarities
Belongs to the PNP/UDP phosphorylase family.
Tissue Specificity
Predominantly expressed in kidney.
Alternative names
Uridine phosphorylase 2, UPase 2, UrdPase 2, UPP2