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UCN

Function

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Tissue specificity

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).

Cellular localization

  • Secreted

Alternative names

  • Urocortin
  • UCN

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

13458Da

We found 2 products in 1 category

Primary Antibodies

Target

Application

Reactive species

Search our catalogue for 'UCN' (2)

Products

ab283503

Anti-Urocortin antibody [EPR25060-64]

Recombinant
RabMAb
20ul selling size