Uroplakin-1b
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Post-translational modifications
N-glycosylated with high-mannose oligosaccharides.
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Tissue Specificity
Bladder epithelium.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
Uroplakin-1b, UP1b, Uroplakin Ib, UPIb, Upk1b