Uroplakin-3b
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
Sequence Similarities
Belongs to the uroplakin-3 family.
Tissue Specificity
Expression is urothelium-specific.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Alternative names
Uroplakin-3b, UP3b, Uroplakin IIIb, p35, UPIIIb, Upk3b