USO1
Domain
Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain.
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Post-translational modifications
Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.
Sequence Similarities
Belongs to the VDP/USO1/EDE1 family.
Cellular localization
- Cytoplasm
- Cytosol
- Golgi apparatus membrane
- Peripheral membrane protein
- Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.
Alternative names
VDP, USO1, General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, Vesicle-docking protein, TAP